Iran said on Friday that it is ready to restart its nuclear program on an "industrial scale" following Trump's decision to pull out of the deal.
Iran foreign minister Javed Zarif said that he would begin a round of diplomatic talks with the European allies in order to save the deal and at the same time the country would start preparing to restart its program of nuclear enrichment, reports said.
He will meet his counterparts from Germany, France and the UK in Brussels on Tuesday.
Hundreds of thousands of Iranians took to the streets in the largest demonstration on Friday, three days after Trump announced his decision of withdrawing from the Joint Comprehensive Plan of Action (JCPOA).
Protesters burned an American flag and railed against the US and Israel after emerging from Friday prayers in Tehran.
Zarif blamed Trump for dragging the "Middle East into Chaos."
On Thursday, Israel hit "dozens" of Iranian military targets in Syria soon after Iran attacked Israeli military positions in Syria just after might nigh on Thursday, creating greater tensions.
Attacks come shortly after US President Donald Trump announced his decision to withdraw from the Iran nuclear deal.
The nuclear deal, signed in July 2015, was designed to limit Iran's nuclear program in exchange for the removal of international sanctions on Iran.
It was signed between six countries in 2015 - Iran, US, Britain, Germany, Russia, France and China for lifting economic sanctions on Tehran in exchange for limitations to the country's nuclear program.